NOBBLE

Neosubstrate and Oligopeptide Binder Benchmarking for Ligase Engagement

running
jobs
83/100
pairs
6/6 br
RMSD
12.308
valid
1/3
Pinned E3 none GLUE none TARGET none PEPTIDE none

Interactions

The degron against the receptor: every peptide residue that comes within 4.5 angstrom of a receptor residue in the predicted ternary, coloured by closest approach. Hover a cell for the distance, click one to pin the pair and open it in the viewer. Only receptor residues that touch something are shown, because an axis of 1,184 residues of which fourteen are in contact is not a readable map.

PLIP answers a different question and is reported beside it: it is a protein-ligand tool, so it gives the glue's contacts with each protein and has nothing to say about where the degron meets the receptor, which is the interface Δ-ipTM is about.

Canonical fingerprint: CRBN

  • HIS61 matched
  • TRP63 matched
  • TRP69 matched
  • TRP83 matched
  • PHE85 missing

Glue to degron

2 contact(s): ILE5, THR6

CONECT integrity

984 contiguous serials across atoms and TER records, 982 atoms, 19 CONECT records, all references resolvable